Ultrasound Phased Array Control of Thermal Dose: High Efficient Constrained MPC
In this paper, a novel model-based treatment control system that manipulates the focal zone trajectory and intensity of ultrasound phased arrays to safely deliver prescribed thermal dose to the target in the minimum-time was developed. The system is characterized by its time-optimal performance, direct incorporation of normal tissue constraints, and computationally efficient implementation even in the presence of massive amount of magnetic resonance (MR) thermometry measurement data. A set of empirical basis functions is identified during pre-treatment planning using proper orthogonal decomposition (POD). Using the same reduced-order basis, thermal images are compressed and used in the feedback of the treatment controller. The controller has a cascaded structure, with a nonlinear thermal dose controller in the outer loop and a low-dimensional model predictive controller (MPC) in the inner loop. The controller solves on-line optimization problem, which allows for robust delivery of the desired thermal dose despite modeling errors and disturbances. The feasibility and performance of the developed control system were tested in a computer simulated treatment of a three-dimensional (3D) inhomogeneous tissue with ultrasound transducer arrays.
Phased Array Transducer HIFU POD MPC MR Thermometry Reduced-Order
Ran Niu Mikhail Skliar
Real-time Controls & Instrumentation Laboratory, GE Global Research (Shanghai), 201203, China Department of Chemical Engineering, University of Utah, Salt Lake City, UT 84112, USA.
国际会议
The 31st Chinese Control Conference(第三十一届中国控制会议)
合肥
英文
4102-4107
2012-07-01（万方平台首次上网日期，不代表论文的发表时间）