Gradient Method Optimization of Penicillin Production
A fermentation process is generally de.ned as a biological process containing the growth of the biomass (bacteria, yeasts) resulting from the consumption of essential substrate supplies (source of carbon, nitrogen, oxygen, etc.). The biomass growth is usually followed by the production of various products from which especially the variety of antibiotics makes the fermentation processes attractive for the industrial utilization. However, the complicated dynamics, high level of uncertainty and nonlinearity and dif.cult online measurement of the process variables come hand in hand with the attractivity and turn the attempts on optimal control of the fermentation process into a very delicate challenge. To tackle it, the theory of the gradient projection method has been partially adapted and fully implemented by the authors of this paper. Numerical experiments show its signi.cantly better performance than for other known methods. Moreover, these experiments reveal an interesting superprofile visible for long cultivation times.
Fermentation process penicillin gradient method optimization
Matej P(c)olka Sergej (C)elikovsk(y)
Department of Control Engineering, Faculty of Electrical Engineering, Czech Technical University in Institute of Information Theory and Automation, Prague, Czech Republic
国际会议
The 24th Chinese Control and Decision Conference (第24届中国控制与决策学术年会 2012 CCDC)
太原
英文
74-79
2012-05-23（万方平台首次上网日期，不代表论文的发表时间）