UKF-based Adaptive Electric Fields Control of Desynchronization for the PR Model under the Ephaptic Transmission
The applied electric field (EF) has shown to have great influence on epileptiform firing. Epilepsy is a dynamical disease charactered by hypersynchronous firing. Taking the electrical characteristic of extracellular medium i.e. ephaptic transmission into consideration, we build a PR model in the presence of the applied electric field. (V-)out DS is the DC part of the voltage between soma and dendrite that electric field takes effect on PR neuron. In this paper we find (V-)out DS is the key parameter that affects the neuronal synchronization and use Unscented Kalman Filter (UKF) to estimate it, then based on key parameter we design a closed-loop control to desynchronize neuronal firing . It is found that the control can not only desynchronize neuronal network, but also can adjust the strength of applied electric field according to the degree of synchronization.
Epilepsy Ephaptic transmission PR model Synchronize UKF Control
Xile Wei Jian Cheng Jiang Wang Bin Deng Meili Lu Yanqiu Che
School of Electrical Engineering and Automation, Tianjin University, Tianjin 300072 Tianjin Key Laboratory of Information Sensing & Intelligent Control, School of Automation and Electr
国际会议
The 24th Chinese Control and Decision Conference (第24届中国控制与决策学术年会 2012 CCDC)
太原
英文
2451-2456
2012-05-23（万方平台首次上网日期，不代表论文的发表时间）