Accurate Mass Analysis of Chlorination By-Products of Fenitrothion
Fenitrothion 0,0-dimethyl 0-(3-methyl-4-nitrophenyl)phosphorothioate, a typical organophosphorus pesticide, is widely used as an insecticide in Japan. In this study, 3-methyl-4-nitrophenol (3M4NP), which is a typical hydrolysate of fenitrothion, was focused as a possible mutagen precursor because it is reported as a common contaminant in raw water for water works, and is capable of forming mutagens when it is chlorinated in water works. In order to examine molecular formulae of mutagens produced from 3M4NP, a chlorinated 3M4NP sample was analyzed with a high-resolution LC/MS. Several peaks were found in a base peak chromatogram for a negative ion mode analysis. Possible by-products of 2,5-dihydroxybenzaldehyde and pyrogallol were found from a chlorinated sample of 3M4NP. The mutagenicity of these substances were positive with the Ames Salmonella assay without metabolic activation.
accurate mass analysis Ames test collision induced disassociation mutagen formation potential mutagenicity
Hirokazu TAKANASHI Kazuya ABIRU Hanako TANAKA Misako KISHIDA Tsunenori NAKAJIMA Akira OHKI Takashi KONDO Takashi KAMEYA Taku MATSUSHITA
Department of Chemistry, Biotechnology, and Chemical Engineering, Graduate School of Science and Eng Division of Natural Environment and Information, Faculty of Environment and Information Sciences, Yo Department of Environmental Engineering, Graduate School of Engineering, Hokkaido University,N13W8,
国际会议
深圳
英文
65-74
2012-04-13（万方平台首次上网日期，不代表论文的发表时间）