The Simulation of the relevance of absorption rate constant and elimination rate constant to the plasma drug concentration

摘要：

To investigate how the concentration characteristics vary with the changing parameters absorption rate constant (Ka) and elimination rate constant (K10) this study simulates a twocompartntent model with first-order absorption for oral administration. Based on the MATLAB software the simulations illustrated the results of the variation of the concentration characteristics in two- and three-dimensional diagrams. It was showed that the peak plasma concentration (Cmax) increased and the time required to reach this peak (Tmax) decreased with the increasing Ka. However, with increasing K10 both the Cmax and the Tmax decreased. Results demonstrate that the profiles are meaningful for the selection of the rational range of Ka and K10, and the identification of the flip-flop kinetic.

关键词： Simulation Pharmacokinetic Two-compartment model Absorption rate constant Elimination rate constant

作者: Lei Zhao Xinling Shi Junhua Zhang Lei Zhao

作者单位: School of Information Science and Engineering Yunnan University Kunming, China School of Science Kunming University of Science and Technology Kunming, China

会议类型: 国际会议

会议名称: 2012 International Conference on Computer Science and Electronic Engineering(2012 IEEE计算机科学与电子工程国际会议 ICCSEE 2012)

会议地点: 杭州

会议语种:英文

页码: 420-424

在线出版日期: 2012-03-23（万方平台首次上网日期，不代表论文的发表时间）