Colon-Targeted Drug Delivery Microparticles Prepared Using Electrohydrodynamic Atomization
Electrohydrodynamic atomization (EHDA) process was exploited to prepare drug-loaded microparticles for colon-targeted drug delivery. Field emission scanning electron microscope results showed that the particles had a size of 1.3±0.7 urn. Differential scanning calorimetry (DSC) analyses and wide-angle Xray diffraction analyses (XRD) results similarly demonstrated that the drug DS had been totally converted into an amorphous state in the EHDA microparticles with Eudragit? L-100 as the polymer matrix. Attenuated total reflectance Fourier transform infrared analysis disclosed that the secondary interactions presented between DS and Eudragit? L100 molecules. In vitro dissolution tests verified that the microparticles had a pH-dependent and sustained drug release profile. The present study provides an easy way for developing colon-targeted drug delivery microparticles.
Electrohydrodynamic atomization Microparticles Colon-targeted Drug delivery Polymer composite
Dengguang Yu Xia Wang Ping Lu Xiao Chen Huipeng Zhao Xiaoyan Li Wei Qian Ying Li Yaozu Liao
School of Material Science & Engineering, University of Shanghai for Science and Technology, Shangha Center of Analysis & Measurement, Donghua University, Shanghai 201620, China
国际会议
合肥
英文
1663-1667
2011-09-23（万方平台首次上网日期，不代表论文的发表时间）