The preparation of pH- and thermo-sensitive chitosan-based hydrogels by Michael-Type Addition Reaction
The hydrogels based on chitosan were prepared by Michael-type addition reaction between chitosans primary amino groups and maleimide group terminating poly(ethylene glycol) (PEG) under mild conditions. The hydrogels were characterizatied by FTIR, TG, etc. The study on the swelling behavior indicated that the hydrogels possess pH- and thermo-sensitivity. The chitosan-based hydogels crosslinked by Michael-type addition reaction have a potential application on biomaterials due to its biodegradability, biocompatibility, less toxicity and hydrophilicity.
Chitosan Hydrogels Michael-Type Addition Swelling Ratio
Hong-Liang Wei Cun-Cai Ma Hui-Juan Chu Jing Zhu
School of Chemistry and Chemical Engineering, Henan University of Technology Zhengzhou 450001, PR China
国际会议
合肥
英文
2392-2395
2011-09-23（万方平台首次上网日期，不代表论文的发表时间）