A MECHANOCHEMICAL MODEL OF THE MICROTUBULE GROWTH DYNAMIC

摘要：

Microtubule dynamics is largely influenced by the hydrolysis of nucleotides bound on tubulins and the associated configuration changes.The growthstabilizing mechanism considering the hydrolysis effect is supposed as a GTP cap model.Meanwhile,there exists an open sheet structure curving outward at the end of the microtubule.and the growth process experiences a sheet-to-tube curvature transition.This growth mode may also help stabilize the growth,which is referred to as a conformational cap model.Here,we present a novel mechanochemical model 10 simulate the microtubule growth process at the resolution of monomer,and look into the stabilizing mechanism of the microtubule growth.

关键词： microtubule growth,dynamic instability,stabilizing mechanism,sheet-to-tube transition,mechanochemical model

作者: X.Q.Feng X.Y.Ji

作者单位: Department of Engineering Mechanics,Tsinghua University,Beijing 100084,China

会议类型: 国际会议

会议名称: The Third International Conference on Heterogeneous Material Mechanics(第三届国际非均匀材料力学会议)

会议地点: 上海

会议语种:英文

页码: 552-555

在线出版日期: 2011-05-22（万方平台首次上网日期，不代表论文的发表时间）