Inhibitory Effect of Hydroxyapatite Nanoparticles on K562 Cells

摘要：

HAP nanoparticles was synthesized by homogeneous precipitation. The size distribution, crystallization degree and morphology of the precipitation were characterized by laser granularity instrument, X-ray diffraction (XRD), and transmission electron microscope (TEM) respectively. The prepared HAP nanoparticles were used for the treatment of human chronic myeloid leukemia K562 cells. The inhibition effect of the nanoparticles on the proliferation of K562 cells was measured by MTT assay and growth curve test. The results showed that the HAP nanoparticles inhibit the proliferation of K562 cells dramatically in vitro. The likely inhibition mechanism of HAP nanoparticles on the K562 cells is that the nanoparticles entered into the dells, induced a series of cell changes, through cell death of apoptosis, oncosis and autoschizis, thus led to the death of K562 cells.

关键词： hydroxyapatite (HAP) nanoparticles K562 cells MTT assay cell cycle

作者: Dai Honglian Chen Pei Han yinchao Wang Xinyu Li Shipu

作者单位: Biomedical Materials and Engineering Research Center,Wuhan University of Technology, China, 430070

会议类型: 国际会议

会议名称: 11th IUMRS International Conference in Asia(第十一届国际材联亚洲材料大会 IUMRS-ICA 2010)

会议地点: 青岛

会议语种:英文

页码: 352-356

在线出版日期: 2010-09-25（万方平台首次上网日期，不代表论文的发表时间）