Study on the Cytotoxicity In-vitro of Composite Materials Based on Poly(L-lactide-co-glycolide) and Bioactive Glass

摘要：

The effect of poly(L-lactide-co-glycolide)/bioactive glass (PLGA/BG) on cell attachment , proliferation and differentiation of L929 fibroblastic cells was investigated. The results of in-vitro cytotoxicity test indicated that the cells cultured in extract of PLGA/BG and on the surface of composite showed normal growth and proliferation. The cell proliferation and alkaline phosphatase (ALP) activity of fibroblast were significantly improved after 3 and 7 days of culture on PLGA/BG films in comparison with PLGA films. It can be concluded that the addition of bioactive glass into PLGA stimulates the proliferation and differentiation of fibroblastic cells. Therefore, PLGA/BG composites have a promising biological response as a potential biomaterial in medical field.

关键词： cytotoxicity in-vitro bioactive glass poly (L-lactide-co-glycolide)

作者: Zhihua Zhou Yongyi Gao Qingfeng Yi Qingquan Liu Lihua Liu

作者单位: Key Laboratory of Theoretical Chemistry and Molecular Simulation of Ministry of Education,School of School of Physics, Hunan University of Science and Technology, Xiangtan 411201, China Key Laboratory of Theoretical Chemistry and Molecular Simulation of Ministry of Education, School of

会议类型: 国际会议

会议名称: 11th IUMRS International Conference in Asia(第十一届国际材联亚洲材料大会 IUMRS-ICA 2010)

会议地点: 青岛

会议语种:英文

页码: 384-389

在线出版日期: 2010-09-25（万方平台首次上网日期，不代表论文的发表时间）