Tetracycline Double Labelling Tracing Investigation for In Vivo Osteogenetic Course of PDLLA/HA Composite

摘要：

The PDLLA(DL-Poly lactic acids)/HA(Hydroxyapatite) composite and pure PDLLA control were implanted in bone for test. Using fluorescent pictures of tetracycline double label and advanced image analysis system, the trend of bone-formation rate for the implanting region of PDLLA/HA composite was obtained via morphometry measurement of the slices labeled with tetracycline. The investigation and calculation results show that, the formation rate of new bone is stable and high (reaches 2.044μm/day) in the early stage of implantation for the PDLLA/HA composite, demonstrating the advantageous capability of bone formation for the composite. The formation rate of new bone seems to decrease continuously with time, and then the bone formation and bone decomposition tend towards equilibration. Namely, the dynamic balance of bony tissue’s metabolism is maintained.

关键词： PDLLA/HA composite biodegradation osteogenetic rate tracing

作者: Xinyu Wang Xuezhi Shan Yingchao Han Shipu Li

作者单位: Biomedical Materials and Engineering Research Center, Wuhan University of Technology,Wuhan 430070, C Biomedical Materials and Engineering Research Center, Wuhan University of Technology, Wuhan 430070,

会议类型: 国际会议

会议名称: 11th IUMRS International Conference in Asia(第十一届国际材联亚洲材料大会 IUMRS-ICA 2010)

会议地点: 青岛

会议语种:英文

页码: 394-398

在线出版日期: 2010-09-25（万方平台首次上网日期，不代表论文的发表时间）