Anti-dementia Compounds from the Mushroom Hericium erinaceum

摘要：

Our group has conducted some studies to search for anti-dementia compounds from medicinal mushrooms since 1991. A series of benzyl alcohol derivatives named as hericenones C to H, as well as a series of diterpenoid derivatives named as erinacines A to I were isolated from the mushroom Hericium erinaceum. These compounds remarkably induced the synthesis of NGF in vitro and/or in vivo. In a recent study, we isolated dilinoleoyl-phosphatidylethanolamine from the mushroom, which protected against neuronal cell death caused by amyloid-peptide toxicity, endoplasmic reticulum (ER) stress, or oxidation stress. Furthermore, the results in clinical trials showed that the mushrrom was effective for patients with dementia

关键词： Anti-dementia Hericium erinaceum Hericenone Erinacine

作者: Hirokazu Kawagishi

作者单位: Graduate School of Science and Technology, Shizuoka University, Shizuoka, Japan

会议类型: 国际会议

会议名称: The 18th Congress of the International Society for Mushroom Science(第十八届国际食用菌大会 ISMS18)

会议地点: 北京

会议语种:英文

页码: 448-456

在线出版日期: 2012-08-27（万方平台首次上网日期，不代表论文的发表时间）