Real-time Monitoring of Benzylpenicillin Sodium Degradation Using Raman Spectroscopy

摘要：

The discovery and development of beta-lactam antibiotics are among the most significant and successful advances in modern medicine. It has saved countless lives and continues to be a backbone of therapy for bacterial infections. Benzylpenicillin sodium, acted as the major component of this family of beta-lactam antibiotics, has been in constant clinical use. However, benzylpenicillin sodium may be dangerous if it degrades in water over time. In this work, Raman spectroscopy was applied to monitor the real-time variation of the benzylpenicillin sodium solution. Here principal components analysis (PCA), a multivariate analysis technique, was used to obtain a more detailed interpretation of the Raman spectra. This study provided a new idea and method in the research of benzylpenicillin sodium degradation.

关键词： benzylpenicillin sodium principal components analysis raman spectroscopy

作者: Weizi Liang Xiaoyun Chen Yu Guo Wang Lin Tao Xue

作者单位: Department of Biomedical Engineering College of Precision Instruments and Optoelectronics Engineerin Analysis Center Tianjin University Tianjin, China

会议类型: 国际会议

会议名称: The 2012 International Conference of Agricultural Engineering and Food Engineering(2012年国际农业工程与食品工程学术会议 ICAE 2012)

会议地点: 哈尔滨

会议语种:英文

页码: 922-925

在线出版日期: 2012-06-16（万方平台首次上网日期，不代表论文的发表时间）