Understanding Centrality-Lethality Rule in Yeast Protein-Protein Interaction Network by Topological Property

摘要：

One of the most important problems in biology is to discover the relationship between topological properties and functional features of proteins in Protein-Protein Interaction (PPI) network. The centrality-lethality rule reveals that hub proteins tend to be more essential than non-hub proteins. Why hub proteins tend to be more essential? Here, we classified hub proteins into two types: essential hub and nonessential hub. We found that essential hubs are more important to the survival of the cell and they can be called intra-modular hubs while nonessential hubs tend to be inter-modular hubs.

关键词： protein-protein interaction network essential hub nonessential hub centrality

作者: DONG Yun-yuan Wang Zheng-hua LIU Qi-jun WANG Yong-xian

作者单位: School of Computer, National University of Defense Technology, Changsha, China Department of Chemistry and Biology, School of Science, National University of Defense Technology, C

会议类型: 国际会议

会议名称: 2011 6th Joint International Information Technology and Artificial Intelligence Conference(2011年第六届IEEE联合国际信息技术与人工智能会议 IEEE ITAIC 2011)

会议地点: 重庆

会议语种:英文

页码: 619-621

在线出版日期: 2011-08-20（万方平台首次上网日期，不代表论文的发表时间）