PTEN and Tumor

摘要：

PTEN was the firstly found cancer suppressor gene with dual-specificity phosphatase (DPS) activities. The gene bas connection with the sporadic tumors and hereditary diseases characterized by tumor-like growth in humans. PTEN can specifically dephosphorylate the phosphatidyIinositol-3, 4, 5-triphosphoric acid PIP3, and antagonize PI3K-AKT signaling pathway to be at work, and hence regulates the growth, multiplication, migration and apoptosis of cells. PTEN mutations are mainly reflected in genie mutation and heterozygous losses, which is involved in the occurrance, development and prognosis of multiple tumors.

关键词： cancer suppressor gene PTEN tumor phosphatase

作者: Zhang Sisen

作者单位: Zhengzhou Peoples Hospital, Zhengzhou, Henan 45003

会议类型: 国际会议

会议名称: 2011 3rd International Conference on Computer Engineering and Applications(2011第三届计算机工程与应用国际会议 ICCEA2011)

会议地点: 海口

会议语种:英文

页码: 30-32

在线出版日期: 2011-07-15（万方平台首次上网日期，不代表论文的发表时间）