An Improved 3D Genome Structure Model

摘要：

To study the genome structure in three-dimensional (3D) space and its relation to biological functions, a variety of experimental approaches, such as biochemical methods, electron microscopy, fluorescent in sjtu hybridization (FISH) and chromosome conformation capture (3C)-based methods, are utilized together to probe the hierarchical order of 3D genome organization with resolution ranging from DNA atomic segment to nuclei chromosome. The advances of experiments are providing us with more data on how global chromosomal architecture is organized in 3D space, and opening the opportunities to predict 3D genome structure by computational methods of data integration. However, integrating data from these disparate experiments is a challenge due to the significant differences and even discrepancies among them, e.g. available data number, resolution scale, credibility and noise.

作者: Cheng Peng Liang-Yu Fu Shuang-Yin Wang Hong-Yu Zhang

作者单位: College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070,P.R.China

会议类型: 国际会议

会议名称: International Symposium on Integrative Bioinformatics the 8th Annual Meeting(2012年整合生物信息学国际会议暨第八届年度会议 IB 2012)

会议地点: 杭州

会议语种:英文

页码: 106-107

在线出版日期: 2012-04-02（万方平台首次上网日期，不代表论文的发表时间）