Lithium Delivery Enhances Bone Growth during Midpalatal Expansion
Lithium is an activator of P-catenin signaling, and P-catenin mediates bone acquisition in response to mechanical loading in the bone. We tested the hypothesis that lithium enhances new bone formation during midpalatal suture expansion. Forty-eight Wistar rats with or without suture expansion were gavagc-fcd daily with lithium chloride or sodium chloride. We labeled the rats with bromo-deoxyuridine to evaluate the proliferation and differentiation of the osteoprogenitors. Lithium increased P-catenin expression and cell proliferation in expanding sutures. Initial delay in the differentiation of osteoprogenitors into mature osteoblasts by lithium treatment corresponded with expansion of preosteoblasts, which preceded the increase of new bone formation in the suture. These results suggested that p-catenin regulates proliferation of osteoprogenitors and maturation of osteoblasts during midpalatal suture expansion osteogenesis, and that lithium enhances bone regeneration by elevating p-catenin expression. Lithium treatment could be a pharmaceutical aid to . improve the stability of orthodontic treatment like rapid palatal expansion.
lithium p-catenin osteoblast proliferation differentiation.
G.H. Tang J. Xu RJ. Chen Y.F. Qian G. Shen
Department of Orthodontics. College of Stomatology, Ninth Peoples Hospital, Shanghai Jiao Tong Univ Department of Orthodontics. College of Stomatology, Ninth Peoples Hospital, Shanghai Jiao Tong Univ
国际会议
上海
英文
61-66
2011-12-28（万方平台首次上网日期，不代表论文的发表时间）