Malignant transformation of oral epithelial dysplasia: clinicopathological risk factors and outcome analysis in a retrospective cohort of 138 cases
Aims: To explore the usefulness of a new binary system of grading dysplasia proposed by the World Health Organization and to identify significant risk factors for malignant transformation in a long-term follow-up cohort of patients with oral epithelial dysplasia. Methods and results: A total of 138 patients with histologically confirmed oral dysplasia between 1978 and 2008 were reviewed retrospectively in our department. The mean follow-up period was 5.1 years. Of these dysplasias. 37 (26.8％) developed into cancer, with a mean duration of 4.6 years. Cox regression analysis revealed that high-grade dysplasia was an independent risk factor for transition, but age, gender, lesion site, diet habit, smoking and alcohol intake were not risk factors.
malignant transformation oral cancer oral epithelial dysplasia potentially malignant disorder risk factor
Wei Liu Zhe-Xuan Bao Lin-Jun Shi Guo-Yao Tang Zeng-Tong Zhou
Department of Oral Mucosal Diseases, Ninth Peoples Hospital, Shanghai iao long University School of Medicine. Shanghai Key Laboratory of Stomatology, Shanghai, China
国际会议
上海
英文
83-90
2011-12-28（万方平台首次上网日期，不代表论文的发表时间）