Letter to the Editor
Thaiidomide induces apoptosis in human oral squamous cell carcinoma cell line with altered expression of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) Thaiidomide, alone or in combination with other agents, has been used successfully to treat patients with multiple myeloma,1-4 and has been extended to the treatment of patients with some solid tumors.57 But data about the effects of thaiidomide on oral squamous cell carcinoma (OSCC) is scarce. There are studies which reported that thaiidomide as a single agent had no activity in squamous head and neck cancer.8-9 However, the populations used for the evaluation of anti-tumour efficacy in these studies were advanced head and neck squamous cell carcinomas. Effects of thaiidomide on such type of malignancy may be underestimated. We used in vitro approaches to investigate whether it has any prohibitory properties on OSCC cells and whether its inhibitory effect on this type of malignancy is related with its pro-apoptosis effect.
Ya Yang Ya-qin Zhu Long Jiang Li-fen Li Jian-ping Ce
Department of General Dentistry. Ninth Peoples Hospital, School of Stomatology, Shanghai Jiao Tong Department of Endodontics, Tongji Hospital of Stomatology, Tongji University 39S Middle Yanchang Roa
国际会议
上海
英文
133-134
2011-12-28（万方平台首次上网日期，不代表论文的发表时间）