Effects of Intensity-modulated Radiotherapy on Human Oral Microflora
PCRDGGE/Bacterialcommunities/Radiotherapy/Hyposalivation. This study aimed to evaluate changes in the biodiversity of the oral microflora of patients with head and neck cancer treated with postoperative intensity-modulated radiotherapy (IMRT) or conventional radiotherapy (CRT). Pooled dental plaque samples were collected during the radiation treatment from patients receiving IMRT (n = 13) and CRT (n = 12). Denaturing gradient gel electrophoresis (DGGE) was used to analyze the temporal variation of these plaque samples. The stimulated and unstimulated salivary flow rates were also compared between IMRT and CRT patients. Reductions in the severity of hyposali-vation were observed in IMRT patients compared with CRT patients. We also observed that the temporal stability of the oral ecosystem was significantly higher in the IMRT group (69.96 ± 7.82％) than in the CRT group (51.98 ± 10.45％) (P < 0.05). The findings of the present study suggest that EVIRT is more conducive to maintaining the relative stability of the oral ecosystem than CRT.
Zi-Yang SHAO Zi-Sheng TANG Chao YAN Yun-Tao JIANG Rui MA Zheng LIU Zheng-Wei HUANG
Division of Radiation Oncology, Department of Oral and Maxillofacial Surgery, Ninth Peoples Hospita Department of Endodontics, Ninth Peoples Hospital, Shanghai Jiao Tong University School of Medicine Department of Oncology, the Affiliated Hospital of Medical College, Qingdao University. No. 308 Ning
国际会议
上海
英文
247-252
2011-12-28（万方平台首次上网日期，不代表论文的发表时间）