Oral melanotic macule and primary oral malignant melanoma: Epidemiology, location involved, and clinical implications
Background. Oral malignant melanoma must be differentiated from melanotic macule. Study design. Retrospective review of 2 series of oral melanotic macule (n = 52) and oral melanoma (n = 130) were conducted to investigate the epidemiology and location involved and assess their differences. Results. The mean age of oral melanotic macule patients was 47.3 years, with female:male ratio 2.1 and the lower lip being the predominant location. The mean age of oral melanoma patients was 53.8 years, with no observed sex predilection and the main locations being palate and gingiva. Differences between the 2 cohorts in age (P = .006), gender (P = .014), and lesion site (P < .001) were noted. In this review, 1 case of oral melanotic macule was found to subsequently develop into melanoma. Conclusions. Oral melanotic macule may possess malignant potential. Biopsy is recommended to differentiate oral melanoma from melanotic macule for male patients >60 years old with suspected melanotic macule lesion located on the palate.
Zheng-Yu Shen Wei Liu Zhe-Xuan Bao Zeng-Tong Zhou Li-Zhen Wang
Department of Dermatology, Ninth Peoples Hospital Department of Oral Mucosal Diseases Department of Oral Pathology
国际会议
上海
英文
301-305
2011-12-28（万方平台首次上网日期，不代表论文的发表时间）