Squamous cell carcinoma development in previously diagnosed oral lichen planus: de novo or transformation?
Objectives. The objectives of this study were to investigate the incidence of oral squamous cell carcinoma (OSCC) developing in lesions that were previously diagnosed as oral lichen planus (OLP), and to evaluate potential contributing factors that might be associated with an increased risk for the development of OSCC in these patients. Study design. We retrospectively reviewed a relatively large cohort of 518 patients with OLP who received long-term follow-up (range, 6 months-21.5 years). Results. There were 353 females and 165 males. Of these, 5 (0.96％) patients developed OSCC with a mean duration of 70 months. All were females with no history of smoking or alcohol use. Four of them received corticosteroid therapy. Notably, 1 of these patients received systemic corticosteroid therapy 13 months before transformation, and died of metastatic disease 46 months after transformation. Conclusions. The incidence of OSCC developing in lesions previously diagnosed as OLP is less than 1％, and females were more commonly affected. These cases appear to represent the transformation of OLP into OSCC, however it cannot be entirely ruled out that these cases may represent de novo OSCC.
Zheng-Yu Shen Wei Liu Jin-Qiu Feng Hai-Wen Zhou Zeng-Tong Zhou
Department of Dermatology, Ninth Peoples Hospital, Shanghai Jiao Tong University School of Medicine Department of Oral Mucosal Diseases, Shanghai Key Laboratory of Stomatology, Ninth Peoples Hospital Department of Oral Mucosal Diseases, Shanghai Key Laboratory of Stomatology, Ninth Peoples Hospital Department of Oral Mucosal Diseases, Shanghai Key Laboratory of Stomatology, Ninth Peoples Hospital
国际会议
上海
英文
307-311
2011-12-28（万方平台首次上网日期，不代表论文的发表时间）