Malignant potential of oral and labial chronic discoid lupus erythematosus: a clinicopathological study of 87 cases
Aims: To investigate clinicopathological features and identify clinicopathological risk factors for the malignant transformation of oral and labial chronic discoid lupus erythematosus (DLE) in a relatively large number of patients from China. Methods and results: A total of 87 patients with clinical and histopathological diagnosis of DLE between 1993 and 2009 were reviewed retrospectively in our hospital. The average age at diagnosis was 51.7 years, with a male:female ratio of 1:1.8. The lower lip was the most common site (71.3％). We documented six DLE patients with malignant transformation. On univariate analysis, patients with high-risk dysplasia (P = 0.002) or aged >60 (P = 0.045) were associated with DLE malignant transformation, but gender, lesion site, smoking and alcohol intake were not risk factors. On multivariate analysis, high-risk dysplasia was a significant indicator for DLE malignant transformation. High-risk dysplasia was associated with a 14.24-fold 95％ confidence interval (95％ CI). 1.97-102.88; P = 0.008 increased risk of malignant transformation, compared with non/low-risk dysplasia. Conclusions: The utilization of high-risk dysplasia as a significant indicator for evaluating malignant transformation risk in patients with DLE is suggested, which may be helpful to guide treatment selection.
discoid lupus erythematosus epithelial dysplasia lip and oral cavity malignant transformation oral cancer
Wei Liu Zheng-Yu Shen Li-Jia Wang Yu-Hua Hu Xue-Ming Shen Zeng-Tong Zhou Jiang Li
Shanghai Key Laboratory of Stomatology, Department of Oral Mucosal Diseases, Ninth Peoples Hospital Department of Dermatology, Ninth Peoples Hospital, SJSM Department of Rheumatology, Renji Hospital, SJSM Department of Oral Pathology, Ninth Peoples Hospital, SJSM, Shanghai, China
国际会议
上海
英文
91-97
2011-12-28（万方平台首次上网日期，不代表论文的发表时间）