A novel approach to rescue immune escape in oral squamous cell carcinoma: Combined use of interferon-y and LY294002
Major histocompatibility complex (MHC) class I molecules have been found to be downmodulated in many tumors. The antigen-processing machinery (APM) genes, especially transporters associated with antigen processing (TAP)-l and tapasin play important roles in the processing of class I antigens. In this study, we investigated the expression of TAP-1 and tapasin in oral squamous cell carcinoma (OSCC); the result indicated significant down-regulation in the expression of these genes. Interferon (IFN)-γ treatment was applied. After the addition of IFN-γ, unexpectedly, the phosphoinositide 3-kinase (PI3KVAKT signaling pathway was activated, which induced the proliferation of tumor cells. With the combined application of LY294002 (specific inhibitor of AKT signaling) and IFN-γ, tumor cell apoptosis was induced and the expression of TAP-1 and tapasin was still up-regulated. Hence, our method is a novel and efficient approach to use IFN-γ for rescuing the cells from immunosurveillance.
oral squamous cell carcinoma antigen processing machinery phosphoinositide 3-kinasc (PI3K)/AKT immune escape
WEI HAN HONGYA PAN LINLIN JIANG KUIJIEWEI DUOHONG ZOU ZHIYUAN ZHANG
Department of Oral and Maxillofacial Surgery, Ninth Peoples Hospital, School of Stomatology, Shangh Department of Oncology, The Second Hospital of Nanjing, No. 1 Zhongfu Road, Nanjing 210003, P.R. Chi School of Stomatology. Tongji University, Shanghai 200011
国际会议
上海
英文
243-249
2011-12-28（万方平台首次上网日期，不代表论文的发表时间）