Does radiation-induced fibrosis have an important role in pathophysiology of the osteoradionecrosis of jaw?

摘要：

Osteoradionecrosis of the mandible is a serious complication following radiation therapy with or without surgical intervention for malignancies of the head and neck. The acknowledged clinical presentation of osteoradionecrosis is pain, fistulae of mucosa or skin, complete devitalization of bone and pathological fractures. Radiation-induced fibrosis is an irreversible pathological process, which leads to damages in lung, skin, intestine, and pelvic cavity after radiotherapy. Studies have proved that radiation-induced fibrosis is involved in the pathological onset, development, maintenance of osteoradionecrosis and there is dose-effect relationship between them, so the authors hypothesize that radiation-induced fibrosis plays an important role in osteoradionecrosis. Studies need to perform to look for more efficient methods of managing and preventing the osteoradionecrosis.

作者: QianWei Zhuang ZhiYuan Zhang HongHai Fu Jie He Yue He

作者单位: Department of Oral and Maxlllofactal Surgery. Ninth Peoples Hospital Affiliated to Shanghai Jiao Tong University, School of Medicine. Shanghai Key Laboratory of Stomatology, 639 ZhiZaoJu Road. Shanghai 200011, China

会议类型: 国际会议

会议名称: The First Session of the 3th Academic Committee Conference of Shanghai Key Lab of Stomatology(上海市口腔医学重点实验室第三届学术委员会第1次会议)

会议地点: 上海

会议语种:英文

页码: 369-371

在线出版日期: 2011-12-28（万方平台首次上网日期，不代表论文的发表时间）