A PIEZOELECTRIC IMMUNOSENSOR BASED ON MICROMACHINED MONOLITHIC FILM BULK ACOUSTIC RESONATOR
Here we develop a novel immunosensor based on film bulk acoustic resonator (FBAR) to detect the biomarker of liver cancer. The alpha-fetoprotein (AFP), which is widely regarded as a serological marker for liver cancer in clinical diagnosis, is chosen as the target of the FBAR immunosensors. The surface of the FBAR was immobilized with monoclonal anti-AFP antibody as the specific bioprobe. The experimental results shows that the limit detectable AFP concentration of our proposed immunosensors is as low as 1 ng/ml, which is far less than that of quartz crystal microbalanc and comparable to that of enzymelinked immunosorbent assay. Due to the compatibility of the fabrication of FBAR with CMOS process it can be mass produced, arrayed for analysis of multiple biochemical analyses simultaneously and integrated into a biochip, so that our proposed FBAR immunosensors can potentially be used for rapid multiple cancers diagnosis with low cost.
Piezoelectric immunosensors Film bulk acoustic resonator Cancer serological marker
Da CHEN Jing-j ing WANG Hong-wei SONG Min LIANG
Qingdao Key Laboratory of Terahertz Technology, College of Science, Shandong University of Science Jinan campus, Shandong University of Science and Technology, Jinan 250010 P R China
国际会议
深圳
英文
113-115
2011-12-09（万方平台首次上网日期，不代表论文的发表时间）