Photoacoustic detection of laser heated tissues ex vivo
Photoacoustic imaging is being investigated as a means to detect and monitor the progress of laser thermal therapy, a minimally invasive treatment for solid tumours that involves heating cancerous tissues to between 55℃ and 95℃ for several minutes resulting in coagulative necrosis. Photoacoustics combines the penetration depth, high resolution and rapid data acquisition of ultrasound with the rich tissue contrast of optical imaging, and has been shown to be sensitive to the mechanical and structural changes that occur in tissues when heated. Here we report on the capability of photoacoustics to distinguish native, coagulated and charred tissue and we provide insight on an optimal wavelength choice, 775nm or 1064nm, for thermal damage detection.
photoacoustics imaging thermal damage coagulation bovine liver
William M. Whelan Michel G. Arsenault Michael C. Kolios P. Michelle Patterson
Physics, University of Prince Edward Island, 550 University Ave. Charlottetown, PEI, CAN, C1A 4P3 Bi Physics, University of Prince Edward Island, 550 University Ave. Charlottetown, PEI, CAN, C1A 4P3 Physics, Ryerson University, 350 Victoria St., Toronto, ON, CAN, M5B 2K3
国际会议
上海
英文
1-3
2011-11-13（万方平台首次上网日期，不代表论文的发表时间）