Design of a Signal Processing Circuit for Quartz Crystal Microbalance Biosensors
In this paper, we design a signal processing circuit for quartz crystal microbalance (QCM) biosensors. The proposed signal processing circuit, which consists of two oscillators, a mixer, a low-pass filter, can be used to measure small amount of QCM biosensors frequency variation at a fundamental resonance frequency. Based on the principle of heterodyne technique, the QCM biosensors frequency variation can be converted into the low frequency composition by a second-order low-pass filter. The output of the low-pass filter is digitized to a stream of digital pulses by a simple digital buffer which represents the corresponding QCM biosensors frequency variation. The proposed signal processing circuit is implemented by 0.35-μm CMOS technology, and the chip layout area is 1060 mm2. In the proposed circuit, the maximum range of the detectable frequency variation is 26 kHz under the resolution of 0.5 Hz. In system verification, the proposed signal processing circuit chip is successfully applied in the signal processing of aAmylase QCM biosensors to detect the change of low concentration biomolecular.
Shih-Chang Chan I-Jen Chao Bin-Da Liu Chun- ueh Huang Mei-Hwa Lee Hung- in Lin
Department of Electrical Engineering, National University of Tainan, Taiwan Department of Electrical Engineering, National Cheng Kung University, Taiwan Department of Materials Science and Engineering, I-Shou University, Taiwan Department of Chemical and Materials Engineering, National University of Kaohsiung, Taiwan
国际会议
2011 IEEE 9th International Conference on ASIC(2011年第九届IEEE国际专用集成电路大会)
厦门
英文
204-207
2011-10-25（万方平台首次上网日期，不代表论文的发表时间）