Selenium Effects on Thyroid Hormone Metabolism and Action

摘要：

Introduction The thyroid gland is among the human tissues with the highest Se concentration (Dickson et al., 1967). A combined deficiency in two essential trace elements, namely iodine and selenium (Se), causes myxedematous cretinism, which isan endemic severe disease in central Africa(Contempre et a!., ?2004). Consequently, nutritional supply with I and Se are considered of central importance for normal thyroid function and thyroid hormone metabolism (K8hrle, 2005). This notion was strengthened when the iodothyroninedeiodinases (DIOs) were identified as being selenoproteins carrying the selenocysteine residue within their catalytic sites (Berry et al., 1991). Final support for the intimate connection of selenoproteins and thyroid hormone metabolism was obtained when the first individuals with genetically impaired selenoprotein expression were reported (Dumitrescu et al., 2005).

作者: Lutz Schomburg

作者单位: Institute for Experimental Endocrinology, Charite - University Medicine, D - 13353 Berlin, Germany

会议类型: 国际会议

会议名称: 第二届硒对环境和人类健康国际会议

会议地点: 苏州

会议语种:英文

页码: 41-42

在线出版日期: 2011-10-23（万方平台首次上网日期，不代表论文的发表时间）