Effects of DON, NIV, T-2 Toxin and Selenium on Integrins, Cytoskeleton Proteins of Chondrocytes, and Sulfate Modification of Cartilage Aggrecan

摘要：

Introduction Kashin-Beck Disease (KBD) is an endemic chronic and unknowingly caused severe progressive osteoarthropathy mainly in China. Clinical symptoms of the disease involve limb joints enlargement, pain and movement restriction. The KBD impacts human health primarily in the Se-deficiency areas from northeast to southwest of China. The characteristic and pathological changes in KBD-infected patients show an over-apoptosis in epiphyseal plate chondrocyle, developmental disorder of secondary ossification endochondrale, and chondrocytes necrosis in the deep layer of articular cartilage. The etiology of KBD is, however, still not clear.

作者: Cao J L Wang J L Li J Luo M X Chen J H Fu Q Zhang Z T Caterson B

作者单位: Institute of Endemic Diseases, Xian Jiaotong University, College of Medicine Key Laboratory of Envi Laboratory of Connective Tissue Biology, School of Biosciences, Cardiff University, Cardiff, CF10 3U

会议类型: 国际会议

会议名称: 第二届硒对环境和人类健康国际会议

会议地点: 苏州

会议语种:英文

页码: 51-52

在线出版日期: 2011-10-23（万方平台首次上网日期，不代表论文的发表时间）