Synthesis of Chlorzoxazone by Selenium-catalyzed Reductive Cyclocarbonylation of 4-Chloro-2-nitrophenol

摘要：

Introduction Chlorzoxazone, (5-chloro-2-benzoxazolone), is a central relaxant widely used in clinical treatment for lumbago, neuralgia, rheumatic arthritis, soft tissue injury, sprain, and spondylopathy caused muscle spasm. Traditionally, synthesis of chlorzoxazone was achieved in two steps starting from 4-chloro-2-nitrophenol: reduction of the nitro group to amino group, followed by cyclocarbonylation of the 4-chloro-2-ami no phenol intermediate.

作者: Li P Ling G Wang X F Yuan X H Lu S W

作者单位: National Engineering Research Center for Catalysis, Dalian Institute of Chemical Physics, Chinese Academies of Sciences, 457 Zhongshan Road, Dalian, Liaoning 116011, China

会议类型: 国际会议

会议名称: 第二届硒对环境和人类健康国际会议

会议地点: 苏州

会议语种:英文

页码: 119-120

在线出版日期: 2011-10-23（万方平台首次上网日期，不代表论文的发表时间）