Studies on functional diversity of plant-specific type-Ⅲ polyketide synthases

摘要：

Plant polyphenols such as chalcone, stilbene, phloroglucinol, chromone, and curcuminoid are one of the largest and important families of natural secondary products. Their chemical structures are rich in variety as well as pharmaceutical activities. Interestingly, recent studies on the biosynthesis of polyphenols have begun to reveal that the remarkable structural diversity of polyphenol scaffolds is produced by a group of chalcone synthase (CHS) superfamily of type-Ill polyketide synthases (PKSs) 1,2). Here, I will introduce structure function relationships and catalytic mechanisms of recently obtained two novel plant-specific type-Ill PKSs.

关键词： polyphenol benzalacetone curcuminoid crystal structure

作者: MORITA Hiroyuki

作者单位: Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033. Japan

会议类型: 国际会议

会议名称: The 6th CCTCNM-KSP-JSP Joint Symposium on Pharmacognosy(第六届中日韩生药学国际学术研讨会)

会议地点: 沈阳

会议语种:英文

页码: 6-7

在线出版日期: 2011-10-21（万方平台首次上网日期，不代表论文的发表时间）