A Study of Cardiac Diffusion Models in Magnetic Resonance Diffusion Imaging
It has been long believed that the decay of diffusion-attenuated signal in MRI complied with monoexponential manner. However, a number of researches found that diffusion signal tended to deviate pronouncedly from monoexponential model with increase of b values in some tissues, such as brain, kidney and prostate. The purpose of the current study was by fitting in each diffusion direction separately in diffusion tensor imaging (DTI), to analyze whether a mono- or biexponential or diffusion kurtosis imaging model gives the best fitting model of DTI in describing diffusion characteristics in normal porcine myocardium. Five non-zero b values between 500 and 2000 s/mm2 were selected and their corresponding myocardial diffusion signal used to fit the three diffusion models in each diffusion direction separately. Statistical tests showed that biexponential model fitted better than the diffusion kurtosis imaging model, and monoexponential model gave the worst fitting performance. The results suggest that diffusion tensor imaging of myocardium may be modeled biexponentially to derive accurate characterization of myocardial microstructure.
Diffusion tensor imaging monoexponential model biexponential model diffusion kurtosis imaging myocardium
Wei Liu Chao Zou Na Zhang Yin Wu Yunxu Sun
Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology Department of Physical Electronics, Harbin Institute of Technology, Shenzhen Graduate School, Shenzh
国际会议
上海
英文
75-78
2011-10-15（万方平台首次上网日期，不代表论文的发表时间）