Deficiency in anterior-posterior connectivity of Default-mode network in amnestic mild cognitive impairment: a combined task-related and resting-state fMRI study
INTRODUCTION :Mild cognitive impairment (MCI) is a transitional stage between normal aging and Alzheimers disease (AD). Recent functional imaging studies have demonstrated regional deactivation magnitudes changes of default-mode network (DMN) in patients, accompanied by a defect of memory function. However, functional connectivity in the DMN during task performance was rarely investigated. METHODS : 26 amnestic MCI and 27 healthy controls underwent functional magnetic resonance imaging (fMRI) during an episodic memory task. Resting-state fMRI data were also collected. The changes in default-mode networks under both task-related and resting-state fMRI were obtained with a temporal correlation analysis. RESULTS: Significantly decreased functional connectivity was found mainly in anterior-posterior connectivity of DMN in aMCI groups. And a correlation existed between the anterior-posterior functional connectivity and MMSE scores. CONCLUSIONS: This study showed that disconnectivity of DMN could be used as an imaging biomarker for predicting the future cognitive decline of aMCI patients.
Mild cognitive impairment Alzheimers disease fMRI default-mode network functional connectivity
Ying Liang He Li Junying Zhang Yao Zhang Tianjiao Feng Xin Li Liang Wang Zhanjun Zhang
State Key Laboratory of Cognitive Neuroscience and Learning Beijing Normal University Beijing 100875 Institute of Basic Research In Clinical Medicine China Academy of Chinese Medical Sciences Beijing 1 State Key Laboratory of Cognitive Neuroscience and LearningBeijing Normal University Beijing 100875, Princeton Neuroscience Institute Princeton University NJ, 08540, USA
国际会议
上海
英文
225-229
2011-10-15（万方平台首次上网日期，不代表论文的发表时间）