Exploration of noninvasive mapping of brain pH with 31P magnetic resonance spectroscopy
Previous study of brain potential of hydrogen (pH) was conducted in single-voxel 31P magnetic resonance (MR) spectroscopy. In this study, we explored the feasibility of mapping brain pH by using multivoxel 31P MR spectroscopy. Firstly, phantom studies were carried out with a GE 3T MR system using 2D PRESSCSI sequence. TR was 1000 msec and TE 144 msec with 128 scan averages. Then two healthy volunteers were studied with same parameters. Data were processed offline using the SAGE/ID L program. Multivoxel spectra were analyzed and brain pH values were calculated with a standard equation. Peaks of metabolite were not homogeneous in phantom studies at this moment. There was noise for multivoxel 31P spectra in volunteer studies. However, phosphomonoester peak, inorganic phosphate peak, phosphodiester peak, and phosphocreatine peak can be identified. Preliminary brain pH map was generated in the volunteers. In our opinion, it is feasible to map brain pH with improved multivoxel 31P MR spectroscopy.
Brain pH magnetic resonance spectroscopy multivoxel mapping
Wu RH Chen YW Ye J Liu WW Shen ZW Qiu QC terBrugge K Kong KM Mikulis DJ
Departments of Radiology, Medical Physics, Surgery, Shantou University Medical College, Shantou, Chi Departments of Radiology, Medical Physics, Surgery, Shantou University Medical College, Shantou, Chi Department of Medical Imaging, Gannan Medical College, Ganzhou, China Corresponding authors: Mikulis Department of Medical Imaging, University of Toronto, Toronto, Canada
国际会议
上海
英文
287-289
2011-10-15（万方平台首次上网日期，不代表论文的发表时间）