Probing Tissue Multifractality Using Wavelet based Multifractal Detrended Fluctuation Analysis:Applications in Precancer Detection
The refractive index fluctuations in the connective tissue layer (stroma) of human cervical tissues having different grades of precancers (dysplasia) was quantified using a wavelet-based multifractal detrended fluctuation analysis model. The results show clear signature of multi-scale self-similarity in the index fluctuations of the tissues. Importantly, the refractive index fluctuations were found to be more anti-correlated at higher grades of precancers. Moreover, the strength of multifractality was also observed to be considerably weaker in higher grades of precancers. These results were further complemented by Fourier domain analysis of the spectral fluctuations.
Fractal Multifractal detrended fluctuation analysis Phase contrast imaging Refractive index Cancer diagnosis.
Jalpa Soni Gregor P. Jose Sayantan Ghosh Asima Pradhan Tapas K. Sengupta Prasanta K. Panigrahi Nirmalya Ghosh
Dept. of Physical Sciences, Indian Institute of Science Education and Research Kolkata (IISER-K),B C Dept. of Biological Sciences, Indian Institute of Science Education and Research Kolkata (IISER-K),B School of Physics, University of KwaZulu-Natal, Private Bag X54001, Durban 4000, South Africa Indian Institute of Kanpur (IIT-K), Kanpur 208 017, India
国际会议
上海
英文
447-451
2011-10-15（万方平台首次上网日期，不代表论文的发表时间）