Analytical Model of Initial Fluid Infusion by a Microneedle Drug Delivery System

摘要：

An analytical model is proposed to calculate the initial infusion of a microneedle array driven by a micropump. By assuming the initial infusion of each microneedle undergoes a spherical expansion, the model is able to calculate the time-varying expansion radius, as well as the flow rate and infusion pressure, provided that the material properties and the microneedle system parameters are known. For a selected piezoelectric micropump, our results show that the expansion under the skin stops and the flow rate drops to zero in a short time. We also found that the initial flow characteristics are strongly influenced by the material properties of the skin and parameters of the drug deliver system.

关键词： component microneedle analytical model micropump

作者: Fenglei Yang Kai Chen Zhi-Gang Feng

作者单位: School of Mechanical Engineering Hangzhou Dianzi University Hangzhou, China Dept. of Mechanical Engineering University of Texas at San Antonio, USA

会议类型: 国际会议

会议名称: 2011 4th International Conference on Biomedical Engineering and Informatics(第四届生物医学工程与信息学国际会议 BMEI 2011)

会议地点: 上海

会议语种:英文

页码: 915-919

在线出版日期: 2011-10-15（万方平台首次上网日期，不代表论文的发表时间）