Modeling Traumatic Brain Injury using a Compressed-Gas Blast Chamber
Blast-induced neurotrauma (BINT) is a common injury modality associated with the current war efforts and increasing levels of terrorist activity. Exposure to the primary blast wave generated by explosive devices causes significant neurological deficits and is responsible for many of the war related pathologies. Despite research efforts, the mechanism of injury is still poorly understood. To this end, we have developed a pressure-driven blast wave generator to analyze the effects of mild blast exposure (500 kilopascals) on rats. This study provides novel evidence linking blast exposure to cellular degeneration in cortical tissue in the absence of functional behavioral deficits. This evidence of degeneration alongside visible hemorrhaging emphasizes the susceptibility of the central nervous system to impulse-like pressure wave insults. Furthermore, such study also highlighted the importance of diagnosing mild brain trauma to recognize, confirm, and treat such conditions in a timely fashion to prevent more severe injury over the time.
Blast Neurotrauma TBI Pressure Wave
Sean Connell Michael Walls Xiang Gao Abeje Ambaw Liang Chen Jinhui Chen Riyi Shi
Weldon School of Biomedical Engineering Dept. Basic Medical Sciences Purdue University, W. Lafayette, IN U.S.A Department of Neurological Surgery Indiana University, Indianapolis, IN U.S.A Stark Neuroscience Research Institute Department of Neurological Surgery Indiana University, Indiana Weldon School of Biomedical Engineering Dept. Basic Medical Sciences Purdue University, W. Lafayette
国际会议
上海
英文
970-973
2011-10-15（万方平台首次上网日期，不代表论文的发表时间）