A Non-invasive Multimodal Sono-contrast NIR Spectroscopy System for Breast Cancer Diagnosis:Clinical Trial
A multimodal spectroscopy system was developed to improve breast cancer diagnosis non-invasively. It includes three modules: diffuse reflectance spectroscopy (DRS), ultrasonography and low intensity focused ultrasound (LIFU). An IRB-approved clinical trial is in progress. Currently 33 patients were enrolled with informed consent. DRS signals were analyzed using wavelet technique before needle biopsy was performed for tissue diagnosis. Clinical results showed that LIFU stimulated transitory high-frequency fluctuation in non-cancer tissue, but not in malignant tissue. The average ratio of the variances during LIFU vs. baseline is 2.95 in non-cancer tissue, compared to 1.18 in cancer. This difference is significant (p=0.0007), indicating that highfrequency fluctuation was amplified in non-cancer tissue during LIFU. Current clinical results demonstrate the effectiveness of this promising technique in characterizing cancer vs. non-cancer tissues. Combining this system with breast ultrasound has the potential to increase the specificity of sonographic breast cancer detection, and to reduce unnecessary invasive procedures.
multimodal imaging system diffuse reflectance spectroscopy low intensity focused ultrasound breast cancer
Kaiguo Yan Yan Yu Lydia Liao
Department of Radiation Oncology,Thomas Jefferson University, Philadelphia, PA, USA Department of Radiology Cooper University Hospital, Voorhees, NJ, USA
国际会议
上海
英文
1029-1032
2011-10-15（万方平台首次上网日期，不代表论文的发表时间）