Development of a Novel Artificial Liver Support System
Background/introduction: Artificial liver support treatment is a promising alternative to liver transplantation. An ideal artificial liver support system (ALSS) should be a combination of a nonbiological liver (NBL) device and a bioreactor based bioartificial liver (BAL). Material and methods: A novel ALSS which can not only fulfill toxin-removal functions of NBL but also provide biotransformation and synthetic functions of BAL is constructed. The unique dual-chamber reservoir can improve the efficiency of material exchange. The funnel-shaped fluidized bed bioreactor can provide an ideal physiological environment for hepatocytes. Quick bubble handling function improves the security during treatment. The software design provides error correction function. Our control center is an industrial personal computer and most components are integrated via the RS485 buses. The whole control system consists of three parts: a pump drive module, a sensor network and a human-machine communication interface. To verify our design, we test the system on miniature pigs. Results: The system runs normally in all treatment modes and meets the clinical requirements. Functions of all components are verified. Conclusions: The system provides a reliable research platform for artificial liver support treatment.
artificial liver support system nonbiological liver bioartificial liver reservoir bioreactor hepatocytes
Lifu Zhao Chengbo Yu Wei Xu Ying Yang Lanjuan Li Jiansheng Xu Tao Song Yang Yu Guoliang Lv Yimin Zhang Anye Zhang Jianzhou Li Pengcheng Zhou Xiaoping Pan Yuemei Chen Xiaopeng Yu
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, Institute of Electrical Engineering Chinese Academy of Science Beijing, 100190, China
国际会议
上海
英文
1087-1091
2011-10-15（万方平台首次上网日期，不代表论文的发表时间）