Drag efficiency of a novel anti-proliferative conjugate: periodate-oxidized chitosan-g-mitomycin C

摘要：

Mitomycin C is an anti-proliferative agent which is usually adopted to prevent fibroblast proliferation in trabeculectomy. However, the shorter half-life of Mitomycin C limits its use. In this paper, a novel anti-proliferative conjugate was synthesized by Schiff base reaction. The cytotoxicity of periodateoxidized chitosan and drug efficiency were also performed by cell proliferation assay, flow cytometry. The results clearly suggested that the conjugate: periodate-oxidized chitosan-g-mitomycin C could be a suitable polymeric system for controlling the release of mitomycin C.

关键词： mitomycin C fibroblast proliferation chitosan controlled release

作者: Lihong Duan Xiaoning Li Qiongjuan Zheng Daping Quan Jian Ge

作者单位: Institute of Polymer Science College of Chemistry and Chemical Engineering, Sun yat- sen University Zhongshan Ophthalmic Center Sun yat-sen University Guangzhou City, China

会议类型: 国际会议

会议名称: 2011 4th International Conference on Biomedical Engineering and Informatics(第四届生物医学工程与信息学国际会议 BMEI 2011)

会议地点: 上海

会议语种:英文

页码: 1216-1219

在线出版日期: 2011-10-15（万方平台首次上网日期，不代表论文的发表时间）