Preparation of small intestinal submucosa as a scaffold for cardiac tissue engineering
In this study, small intestinal submucosa (SIS) was prepared and engineered cardiac tissue was constructed using the SIS as scaffold. SIS was decellularized by mechanical and chemical treatment. Its mechanical capability and biocompatibility were evaluated, and then neonatal rat cardiomyocytes were seeded on SIS, thus the engineered cardiac tissue sheets were constructed in vitro. The results showed that the SIS was decellularized completely; its mechanical capability and biocompatibility were both satisfactory. The engineered cardiac tissue could beat spontaneously for a long time; it was consisted of layers of cardiomyocytes. In conclusion, the SIS with good capability was prepared successfully, and engineered cardiac tissue was constructed successfully based on the SIS scaffold.
Small intestinal submucosa scaffold cardiomyocytes tissue engineering
Qiangcheng Zeng Lu Liu Yong Guo Ruixin Li Juan Sun Chun Guo
Shandong provincial Key lab of biophysics, Dezhou University, Dezhou, PR China Biomaterial Lab, Tianjin Institute of Medical Equipment, Tianjin, PR China
国际会议
上海
英文
1258-1262
2011-10-15（万方平台首次上网日期，不代表论文的发表时间）