Simple Fabrication of PEG-based Chemical Micropatterns for Neural Network Formation

摘要：

Neural network formation has attracted increasing interest for applications in neurotosicology, neurodevelopmental biology, and cell-based biosensors which comprise external microelectronic circuits that stimulate and record neural activity. In this paper, we present a simple and efficient method to create a planar PC12 neural network on well-controlled PEGbased chemical micropatterns which contain a network of regular hexagon units interconnected by microchannels. X-ray photoelectron spectroscopy, contact angle goniometer and fluorescence microscopy techniques are used to monitor the individual steps of the patterning process.

关键词： micropatterning surface modification poly(ethylene glycol) cell adhesion neural network

作者: Ning-Ping Huang Jun-Cai Shi Yan-Yan Wang Hai Yu

作者单位: State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, P.R. China

会议类型: 国际会议

会议名称: 2011 4th International Conference on Biomedical Engineering and Informatics(第四届生物医学工程与信息学国际会议 BMEI 2011)

会议地点: 上海

会议语种:英文

页码: 1263-1266

在线出版日期: 2011-10-15（万方平台首次上网日期，不代表论文的发表时间）