Cathepsin L is up-expressed in atherosclerotic lesion induced by shear stress.
Cathepsin L has been implicated a shear-sensitive matrix protease. However, there was no in vivo evidence available. In this study, ten rabbits were treated with gel-silica loop to develop a defined local stenosis in left carotid arteries straight segment and fed with high fat/cholesterol diet for 4 weeks. Numerical simulation showed that blood flow was disturbed significantly at the immediate proximal and distal vicinity of stenosis. The shear stress in proximal part of ringer was obviously increased (> 6Pa), while the shear stress in distal of ring was decreased (0~0.3Pa). Lesions were observed in both proximal and distal of the stenosis at the end of 4 weeks, however, the lesion from proximal had more macrophage cells and lipid deposition. In proximal lesions, cathepsin L was highly expressedi whereas less cathepsin L was detected in distal lesion. Taken together, shear stress attributed to atherosclerosis. High shear stress induces larger lesions with a vulnerable plaque phenotype, whereas low shear stress induces stable lesions. The differentia expression of cathepsin L may contribute to the feature of atherosclerotic lesion.
Shear stress Stenosis Atherosclerosis cathepsin L
Dangheng Wei Zhihan Tang Xiaoyin Jia Yanghui Liu Lushang Liu Zuo Wang Zhisheng Jiang Yiping Xia Peigeng Gui
The Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Pro University of South China Hengyang, P.R. China
国际会议
上海
英文
1480-1483
2011-10-15（万方平台首次上网日期，不代表论文的发表时间）