In Vitro Anti-Influenza A Virus Activity of Konjac Oligo-glucomannan Sulfate
Glucomannan extracted from konjac was sulfated (konjac oligo-glucomannan sulfate, OGMS) to show selective anti- Influenza A virus activity in vitro using MDCK cell line as the host cell of Influenza A virus. OGMS straight inhibited the virus according to different groups and IAV-RNA Replication in MDCK cell by RT-PCR. The studies indicated that OGMS mainly acted as virus protein inhibitor and its IC50 was 0.03125 mg/mL by Reed-Muench method; IAV-RNA Replication was inhibited as well. All these indicated that OGMS had evident in vitro anti- Influenza A virus activity.
Konjac Polysaccharide sulfate Influenza A virus In vitro
Hao Huang Zhonghua Yang Guanghui Wang Jun Chen
Biological engineering institute,chemical engineering and technology College Wu Han University of Science and Technology Wu Han, China
国际会议
上海
英文
1508-1514
2011-10-15（万方平台首次上网日期，不代表论文的发表时间）