A 3-D Presentation of Protein Secondary Structure Characteristic Sequences

摘要：

Similarity comparison of protein structure is an important problem in computational molecular biology. It plays an important role in predicting the structure and function of protein. This paper introduces a 3-D presentation of protein secondary structure based on eight-letter secondary structure alphabet and applies it to analyze the similarity among three different proteins (LYP, myoglobinlOlM and myoglobinl02M). The result is satisfactory. This method does not rely on the one-dimensional amino acid sequences which we know well completely. But it relies on more conservative eight-letter sequences whose basic unit is protein secondary structure. It is an effective measure to analyze the similarity between two proteins with any structure. Especially, it has realistic significance to compare two proteins that have no sequence similarities.

关键词： Protein secondary structure characteristic sequences 3-D presentation curve fitting

作者: Feng-lan Bai Hua-long Gao Ying Li

作者单位: School of Science, Dalian Jiaotong University Dalian 116028, China

会议类型: 国际会议

会议名称: 2011 4th International Conference on Biomedical Engineering and Informatics(第四届生物医学工程与信息学国际会议 BMEI 2011)

会议地点: 上海

会议语种:英文

页码: 1565-1568

在线出版日期: 2011-10-15（万方平台首次上网日期，不代表论文的发表时间）