Explore the domain features of co-regulation proteins, co-interaction proteins and co-regulation & co- interaction proteins
The interaction between proteins is one of the most important features of protein functions. Behind protein - protein interactions there are relationship among protein domains physically to perform the necessary functions. Accordingly, we focus on our research on the domain features of co-regulation proteins sets, co-interaction proteins sets and coregulation & co-regulation proteins sets. We applied aggregation factors to evaluate the domain features about above three protein sets. By random experiment, we approved that the aggregation factors were significant (p<0.01) in these three protein sets. That is to say, the same domains present more frequency in them than in other protein subsets. Furthermore, our results also showed that the same domains present more frequency in co-regulation & cointeraction subsets than in co-regulation subsets, which indicated that co-regulation protein sets & cointeraction protein sets are more likely protein sets which have the same domains.
Co-regulation Co-interaction Domain features Aggregation factor
Lin Hua Yongbin Liu Lei Gao Dongguo Li
Department of Bioinformatics, Biomedical Engineering Institute Capital University of Medicine Science Beijing, China
国际会议
上海
英文
1587-1591
2011-10-15（万方平台首次上网日期，不代表论文的发表时间）