Preliminary study of Alzheimers disease related genes by using genetical genomics approach
Alzheimers disease (AD), the most common type of dementia is characterized by the progressive loss of specific neuronal populations and accumulation of the intraneuronal inclusions. The genetic factors contributing to AD are largely unknown. To date, we have collected 366 AD related genes based on bioinformatics analysis. Genetical genomics have been used to dissect the genetic modulators of these AD related genes by combination of gene expression profiling in the hippocampus of BXD RI mice in combination with linkage analysis. Of the 366 AD related genes, we identified 126 probe sets that target 76 genes that have a significant linkage score (LRS > 15). Approximately 60％ of these expression differences are caused by potential cis-acting quantitative trait loci (QTLs). The expression of the genes modulated by 30 of the putative cis-QTLs have a fold-difference higher than 1.7 between the parental strains of the BXD - C57BL/6J and DBA/2J. This study provided the baseline data for the accuracy analysis of genetic networks associated with AD that would be of great value for revealing the molecular mechanisms of AD.
Alzheimers disease expression QTL genetical genomics
Ying Chen Yinghong Zhao Xiaodong Wang Yi Li Kaifu Ke Junming Yue Roderick T Hori Lu Lu
Key Lab.of Neuroregeneration,Nantong University,Nantong City,China,226001 Affiliated hospital of Nantong University,Nantong City,China,226001 Department of Physiology,University of tennessee Health Science Certer,Memphis,TN 38163,USA Department of Molecular Sciences,University of Tennessee Health Science Center,Memphis,TN 38163,USA
国际会议
上海
英文
1613-1616
2011-10-15（万方平台首次上网日期，不代表论文的发表时间）