Discovery of MicroRNA Conservative Sites in Drosophila Melanogaster

摘要：

MicroRNAs(MiRNAs) are ~22nt non-coding RNAs which regulate gene expression in numerous species. Several computational approaches have been conducted to predict precursor miRNA secondary structure, discover target gene and study miRNA regulatory mechanism. However, there are few studies for analyzing mature miRNA sites. This paper proposes a novel framework, based on information entropy, to discover mature miRNA site. The structure information and sequence information are both taken into account The important degree of sites is evaluated by information entropy. A lower information entropy usually means the miRNA site is more conservative. The experimental results indicate that our approach is useful to identify mature miRNA sites.

关键词： MicroRNA(MiRNA) information entropy secondary structure conservative site

作者: Wei Lan Qingfeng Chen Taoshen Li

作者单位: School of Computer, Electronic and Information Guangxi University, Nanning, China, 530004

会议类型: 国际会议

会议名称: 2011 4th International Conference on Biomedical Engineering and Informatics(第四届生物医学工程与信息学国际会议 BMEI 2011)

会议地点: 上海

会议语种:英文

页码: 1723-1726

在线出版日期: 2011-10-15（万方平台首次上网日期，不代表论文的发表时间）