Functional Characterization of Hub Proteins in Weighted Yeast Protein-Protein Interaction Networks

摘要：

The centrality-lethality rule reveals that topological prominence of a protein indicates its functional importance. But are all hub proteins in PPI network essential? Using P-value to weight PPI networks, we classified hub proteins into two types: essential hub and nonessential hub. The weighted centrality measure of weighted PPI networks showed that the weighted method can give greater support for functional characterization of hub proteins. We found that essential hubs are vital and they tend to be intra-modular hubs, while nonessential hubs are useful in maintaining the overall network connectivity and tend to be inter-modular hubs.

关键词： weighted protein-protein interaction network essential hub nonessential hub weighted centrality

作者: DONG Yun-yuan LIU Qi-jun YANG Jun WANG Yong-xian WANG Zheng-hua

作者单位: College of Computer, National University of Defense Technology, Changsha, China Department of Chemistry and Biology, College of Science, National University of Defense Technology, No.91 Element of 92941 Troops of the Chinese Peoples Liberation Army, Huludao, China

会议类型: 国际会议

会议名称: 2011 4th International Conference on Biomedical Engineering and Informatics(第四届生物医学工程与信息学国际会议 BMEI 2011)

会议地点: 上海

会议语种:英文

页码: 1741-1744

在线出版日期: 2011-10-15（万方平台首次上网日期，不代表论文的发表时间）